Flexia Tablets 60mg (Etoricoxib) 10 Film Coated Tablets
Description of Flexia 60mg Tablets
Flexia 60mg tablets contain Etoricoxib, a selective COX-2 inhibitor classified under non-steroidal anti-inflammatory drugs (NSAIDs). It is primarily used for the treatment of pain, inflammation, and swelling associated with musculoskeletal disorders. Etoricoxib selectively inhibits the COX-2 enzyme, reducing the production of prostaglandins responsible for inflammation and pain while minimizing gastrointestinal side effects common with non-selective NSAIDs.
Key Features:
- Active Ingredient: Etoricoxib 60mg
- Drug Class: Selective COX-2 Inhibitor (NSAID)
- Therapeutic Use: Anti-inflammatory and analgesic (pain reliever)
- Mechanism of Action: Blocks COX-2 enzyme to reduce inflammation and pain without significantly affecting COX-1, leading to fewer stomach-related side effects.
Uses:
- Osteoarthritis (OA) – Relieves joint pain and stiffness.
- Rheumatoid Arthritis (RA) – Reduces inflammation and swelling in joints.
- Ankylosing Spondylitis – Treats pain and stiffness in the spine.
- Gouty Arthritis – Manages acute attacks of gout pain.
- Acute Musculoskeletal Pain – Provides relief from short-term pain conditions.
Administration:
- Taken once daily with or without food.
- The dose may vary depending on the condition being treated.
Common Side Effects:
- Headache
- Nausea
- Stomach discomfort
- High blood pressure
Precautions:
- Not recommended for long-term use without medical supervision.
- Caution in patients with heart disease, kidney disease, or high blood pressure.
Flexia 60mg is a widely used pain-relieving medication for inflammatory conditions, offering effective pain management with reduced gastrointestinal side effects compared to traditional NSAIDs.
Original price was: ₨220.00.₨212.00Current price is: ₨212.00.
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Flexia 60mg Tablets contain Etoricoxib, a selective COX-2 inhibitor classified under non-steroidal anti-inflammatory drugs (NSAIDs). Manufactured by Ferozsons Laboratories Limited, these tablets are designed to alleviate pain and inflammation associated with various musculoskeletal conditions.
Composition and Form
- Active Ingredient: Etoricoxib 60mg
- Dosage Form: Film-coated tablets
- Packaging: Each pack contains 10 tablets
Therapeutic Indications
Flexia 60mg Tablets are indicated for the relief of pain and inflammation in adults and adolescents aged 16 years and older with:
- Osteoarthritis: Degenerative joint disease causing pain and stiffness
- Rheumatoid Arthritis: Autoimmune condition leading to joint inflammation and pain
- Ankylosing Spondylitis: Chronic inflammation affecting the spine and sacroiliac joints
- Gouty Arthritis: Sudden, severe attacks of pain and swelling in joints due to uric acid crystal deposition
- Acute Musculoskeletal Pain: Short-term management of moderate pain, such as that following dental surgery
Mechanism of Action
Etoricoxib selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, which plays a crucial role in the synthesis of prostaglandins involved in pain and inflammation. By targeting COX-2, Etoricoxib reduces these symptoms while minimizing gastrointestinal side effects commonly associated with non-selective NSAIDs.
Dosage and Administration
- General Dosage: The recommended dose is 60 mg once daily, with or without food.
- Specific Conditions:
- Osteoarthritis, Rheumatoid Arthritis, Ankylosing Spondylitis: 60 mg once daily
- Acute Gouty Arthritis: 120 mg once daily, limited to a maximum of 8 days
- Duration: Use the lowest effective dose for the shortest duration necessary to control symptoms.
Contraindications
- Known hypersensitivity to Etoricoxib or any component of the tablet
- Active peptic ulceration or gastrointestinal bleeding
- Severe hepatic impairment
- Patients with inflammatory bowel disease
- Congestive heart failure, established ischemic heart disease, or cerebrovascular disease
Warnings and Precautions
- Cardiovascular Risk: Etoricoxib may increase the risk of cardiovascular events such as heart attack or stroke, especially with prolonged use or in patients with existing cardiovascular conditions.
- Gastrointestinal Effects: While selective for COX-2, Etoricoxib can still cause gastrointestinal issues, including bleeding, ulceration, and perforation.
- Renal Effects: Caution is advised in patients with pre-existing kidney conditions, as Etoricoxib can cause fluid retention and edema.
- Hepatic Effects: Monitor liver function periodically in patients receiving long-term therapy.
Drug Interactions
- Anticoagulants: Etoricoxib may enhance the effects of blood thinners like warfarin, increasing bleeding risk.
- Diuretics and Antihypertensives: Concurrent use may reduce the effectiveness of these medications.
- Other NSAIDs: Avoid concomitant use with other NSAIDs or COX-2 inhibitors to minimize adverse effects.
Use in Specific Populations
- Pregnancy and Lactation: Not recommended during pregnancy or breastfeeding due to potential risks to the fetus or infant.
- Pediatric Use: Safety and efficacy have not been established in children under 16 years of age.
- Elderly Patients: No dosage adjustment is necessary; however, caution is advised due to the increased risk of adverse reactions.
Storage Conditions
- Store at room temperature (15-30°C) in a dry place, away from direct sunlight.
- Keep out of reach of children.
Conclusion
Flexia 60mg Tablets (Etoricoxib) offer effective relief from pain and inflammation associated with various arthritic and musculoskeletal conditions. While providing targeted COX-2 inhibition, it is essential to use this medication under medical supervision, considering the potential risks and individual patient factors.
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