Acylex Tablets 200mg (Aciclovir b.p) 25 film coated Tablets

Description

Acylex Tablet: Detailed Note

Generic Name: Acyclovir
Brand Name: Acylex
Drug Class: Antiviral

Overview

Acylex is a brand of acyclovir, which is an antiviral medication primarily used to treat infections caused by certain types of viruses. It is effective in managing conditions caused by the herpes simplex virus (HSV) and the varicella-zoster virus (VZV).

Uses of Acylex Tablet

Acylex is prescribed to treat the following conditions:

1. Herpes Simplex Virus Infections
   • Genital herpes (initial and recurrent episodes)
   • Herpes labialis (cold sores)
2. Varicella (Chickenpox)
3. Herpes Zoster (Shingles)
4. Prophylaxis in Immunocompromised Patients
   • Prevents recurrent herpes outbreaks in patients with a weakened immune system.

Mechanism of Action

Acyclovir, the active ingredient in Acylex, works by interfering with the DNA synthesis of the virus. It inhibits viral replication by targeting the viral DNA polymerase enzyme, preventing the virus from multiplying and spreading. It does not cure the infection but reduces the severity and duration of symptoms.

Dosage and Administration

• The dosage of Acylex varies based on the condition being treated and the patient’s medical profile.
• It is generally taken orally, with or without food, with plenty of water to reduce the risk of kidney-related side effects.
• Typical Dosage Recommendations:
  • Genital Herpes: 400 mg three times a day for 7–10 days.
  • Shingles: 800 mg five times a day for 7 days.
  • Chickenpox: 20 mg/kg (up to 800 mg) four times daily for 5 days.
• For best results, it should be started at the first sign of symptoms.

Side Effects

Common side effects include:

• Nausea
• Vomiting
• Headache
• Dizziness
• Fatigue
• Abdominal pain

Rare but serious side effects:

• Kidney dysfunction (increased creatinine levels)
• Neurological symptoms (confusion, hallucinations)
• Allergic reactions (rash, swelling, difficulty breathing)

Precautions

• Kidney Disease: Dose adjustment may be necessary in patients with renal impairment.
• Neurological Disorders: Use cautiously in patients with pre-existing neurological conditions.
• Dehydration: Ensure adequate hydration to prevent kidney issues.
• Pregnancy and Breastfeeding: Consult a healthcare provider as it is generally prescribed if the benefits outweigh the risks.

Drug Interactions

Acylex may interact with:

• Probenecid: Increases acyclovir levels in the body.
• Cimetidine: May reduce acyclovir clearance.
• Mycophenolate Mofetil: May increase the risk of adverse effects.

Storage

• Store at room temperature (20°C to 25°C).
• Keep in a dry place, away from light and moisture.
• Keep out of reach of children.

Conclusion

Acylex is a reliable antiviral medication for the management of herpes simplex, chickenpox, and shingles. While it doesn’t cure these viral infections, it significantly reduces symptoms and speeds up recovery. It is essential to follow the prescribed dosage and complete the full course of treatment for optimal results. Regular monitoring and hydration can help minimize potential side effects.